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Skin, Hair and Appearance

Copper peptides, melanocortin agonists and 5-alpha-reductase inhibitors - three mechanisms with nothing in common but the outcome.

GHK-Cu is the most studied compound here, with a substantial dermatological literature on collagen synthesis and dermal remodelling. It is also the most searched term in this category, and it is frequently combined with other peptides in blended pens.

Melanocortin agonists work on an entirely different axis. Melanotan I is relatively selective for MC1R and therefore for melanogenesis; Melanotan II is non-selective and acts across melanocortin receptor subtypes, which is why its effects extend beyond pigmentation.

Hair loss is a third mechanism again: finasteride inhibits type II 5-alpha-reductase, reducing conversion of testosterone to DHT. It therefore has no effect on compounds that are already 5-alpha reduced or that do not require that conversion, which is a distinction that catches people out.

What to weigh up

GHK-Cu solutions are blue

The copper complex gives a characteristic blue tint. That is expected and is not contamination.

MT1 and MT2 are not interchangeable

MT2 is non-selective, which is precisely why its effects go beyond tanning.

Finasteride only acts on one conversion

It reduces DHT from testosterone. It does nothing to a compound that is already reduced.

Photosensitivity is real

Melanocortin agonists change how skin responds to UV. Existing lesions should be reviewed clinically before use.

Stocked for this goal

Go deeper

This page covers what serves the goal. For what each compound actually is - class, mechanism, half-life and storage - see the reference library.